Table 1.

Complete overview of the 89 Viperinae venom proteomes. The number of studied venom compositions per genus (grey), species, and subspecies (bracketed) are mentioned. Types of different sequence annotations (black bars) and quantification (black dot) are marked for each species. The checklist shows identified toxin families, sorted by their general abundance in the venom of all Viperinae into major, secondary and further toxin families (minor, rare families and peptides). Abbreviations: svMP (snake venom metalloproteinase), PLA₂ (phospholipase A2), svSP (snake venom serine protease), CTL (C-type lectin-related protein), DI (disintegrins), LAAO (L-amino acid oxidase), CRISP (cysteine-rich secretory protein), VEGF (vascular endothelial growth factors F), KUN (Kunitz-type trypsin inhibitor), CYS (cystatin), svMP-i (svMP inhibitor), NP (natriuretic peptides).

										Majors				Secondaries
Genus Species	No. of Compositions	Examined Subspecies	Bottom-Up	Top-Down	Edman Degradation	Q—Snake Venomics	Q—Two-Step Workflows	Q—in-Solution Shotgun	No Quantification	■svMP	■PLA2	■svSP	■CTL	■DI	■LAAO	■CRISP	■VEGF	■KUN	■Minor families	■CYS	■Rare Families	■svMP-i	■NP	■Other Peptides	References
Atheris	3
A. chlorechis	1		■						●	🗸	🗸	-	-	🗸	-	-	-	-	-	-	-	-	-	🗸	[69]
A. nitschei	1		■						●	🗸	🗸	🗸	-	🗸	-	-	-	-	-	-	-	-	-	🗸	[69]
A. squamigera	1		■						●	🗸	🗸	🗸	-	🗸	-	-	-	-	-	-	-	-	-	🗸	[69]
Bitis	9
B. arietans	4		■		■	●		●	●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	[60,75,76,77]
B. caudalis	1		■		■	●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	-	-	-	-	🗸	[78]
B. gabonica	2		■		■	●			●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	-	🗸	🗸	[79,80]
B. nasicornis	1		■		■	●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	🗸	-	-	-	🗸	[78]
B. rhinoceros	1		■		■	●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	🗸	-	-	🗸	🗸	[78]
Causus	2
C. lichtensteinii	1		■						●	🗸	-	🗸	-	-	🗸	🗸	-	-	-	-	-	-	-	-	[81]
C. rhombeatus	1		■						●	🗸	🗸	🗸	-	-	🗸	🗸	-	-	-	-	-	-	-	-	[81]
Cerastes	6
C. cerastes	5		■	■	■	●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	🗸	-	🗸	[76,82,83,84]
C. vipera	1		■		■	●				🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	-	🗸	-	-	[82]
Daboia	24
D. mauritanica	2		■		■	●			●	🗸	🗸	🗸	🗸	🗸	-	-	🗸	🗸	-	-	-	-	🗸	-	[85,86]
D. palaestinae	1		■		■	●				🗸	🗸	🗸	🗸	🗸	-	-	🗸	-	🗸	-	-	-	-	-	[87]
D. russelii	12		■			●	●			🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	🗸	🗸	🗸	[88,89,90,91,92,93,94,95]
D. siamensis	9		■		■	●	●	●	●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	-	-	[68,96,97,98,99,100]
Echis	16
E. carinatus	11	(2)	■	■	■	●	●	●		🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	🗸	🗸	🗸	[76,101,102,103,104,105]
E. coloratus	1		■		■	●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	🗸	-	-	[76]
E. leucogaster	1		■			●				🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	-	🗸	-	-	[106]
E. ocellatus	2		■		■	●			●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	🗸	-	🗸	[76,107]
E. pyramidum	1		■		■	●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	🗸	-	-	[76]
Eristicophis	1
E. macmahoni	1		■						●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	🗸	-	[70]
Macrovipera	5
M. lebetina	5	(2)	■		■	●			●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	🗸	🗸	-	[82,85,108,109,110]
Montivipera	3
M. bulgardaghica	1		■			●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	🗸	-	🗸	[111]
M. raddei	2		■		■	●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	-	🗸	🗸	🗸	[108,111]
Pseudocerastes	2
P. fieldi	1		■						●	🗸	🗸	🗸	🗸	-	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	[70]
P. persicus	1		■						●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	-	-	-	-	[70]
Vipera	18
V. ammodytes	5	(3)	■	■	■	●			●	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	🗸	🗸	🗸	[112,113,114,115]
V. anatolica	2	(2)	■	■		●				🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	🗸	-	🗸	🗸	🗸	🗸	[56,116]
V. aspis	1		■					●		🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	🗸	-	🗸	[117]
V. berus	3		■		■	●	●			🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	🗸	🗸	🗸	[118,119,120]
V. kaznakovi	2		■	■		●		●		🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	🗸	🗸	🗸	🗸	[28,121]
V. nikolskii	1		■					●		🗸	🗸	🗸	🗸	-	🗸	🗸	🗸	🗸	🗸	-	🗸	-	🗸	-	[121]
V. orlovi	1		■					●		🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	🗸	-	[121]
V. renardi	1		■					●		🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	🗸	-	🗸	-	-	-	[121]
V. transcaucasiana	1		■	■		●				🗸	🗸	🗸	🗸	-	🗸	🗸	🗸	-	🗸	-	-	🗸	🗸	🗸	[112]
V. ursinii	1		■				●			🗸	🗸	🗸	🗸	-	-	🗸	-	🗸	🗸	-	🗸	-	-	-	[122]