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. 2021 Jun 17;10(6):1522. doi: 10.3390/cells10061522

Figure 1.

Figure 1

(a) PI3K Class III complexes, subcomplexes, and their associated cellular functions. BECLIN1 is indicated in blue with its protein domains listed. Green arrows indicate functions promoted by complexes, whereas red indicates pathways inhibited by complexes. (b) Yeast C2 crystal structure resolved to 4.40 Å by X-ray diffraction: VPS30 (BECLIN1 homolog, blue), VPS38 (UVRAG homolog, yellow), VPS15 (purple), VPS34 (deep purple). Red helices have been tentatively assigned to the Beclin1 N-terminal region that contains the BH3 domain (PDB ID: 5DFZ).