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(a) Structure of BCL-XL in complex with the BH3 domains of the pro-apoptotic BH3-only protein BIM (blue, PDB: 3FDL) [61] and BECLIN1 (pink, 2P1L) [57]. Both BH3 domains occupy the same binding site. (b) Schematic of proteins that competitively bind BECLIN1 and/or BCL-2 to promote or inhibit this interaction, thereby reducing or enhancing autophagy, respectively.
