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. 2021 Jun 17;10(6):1522. doi: 10.3390/cells10061522

Figure 4.

Figure 4

Ubiquitination events that regulate BECLIN1. E3 ligases that stabilise BECLIN1 protein levels and/or promote autophagy are indicated in green, whereas those with degradative effects on BECLIN1 that downregulate autophagy are indicated in red (note: WASH is the only non-E3 ligase indicated here). DUBs are italicised and also follow the green and red colour code to indicate their pro- or anti-autophagic effects.