Figure 4.
Ubiquitination events that regulate BECLIN1. E3 ligases that stabilise BECLIN1 protein levels and/or promote autophagy are indicated in green, whereas those with degradative effects on BECLIN1 that downregulate autophagy are indicated in red (note: WASH is the only non-E3 ligase indicated here). DUBs are italicised and also follow the green and red colour code to indicate their pro- or anti-autophagic effects.