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The process to generate objective training data. (a) The training annotations for the tissue-level model were generated using IHC when available. For the images from the TCGA-BRCA, the annotations were manually generated by a pathologist. (b) the TILs training annotations were generated as center-dot labels on cells that were either CD3 or CD79a positive to make sure that all mononuclear immune cells were included as stated by the TIL-WG guideline.
