Table 1.
Univariate analysis of the included clinical parameters and biomarkers. 1 Manual score is in increments of 10. 2 sTIL density is continuous but normalized to increments of 300 sTILs/mm2.
| Variable | HR (95% CI) | |||
|---|---|---|---|---|
| OS | p | RFS | p | |
| Age | 3.37 (1.75–6.49) | <0.001 | 1.83 (0.96–3.52) | 0.068 |
| Nodal status | ||||
| 1–3 | 1.61 (1.01–2.55) | 0.043 | 2.04 (1.16–3.57) | 0.013 |
| ≥4 | 4.37 (2.57–7.43) | <0.001 | 4.33 (2.20–8.51) | <0.001 |
| Tumor size | 1.55 (1.00–2.41) | 0.049 | 1.69 (0.98–2.93) | 0.060 |
| Tumor type | ||||
| Ductal vs. lobular | 4.21 (1.32–13.44) | 0.015 | 4.07 (0.98–16.94) | 0.053 |
| Ductal vs. other | 0.95 (0.58–1.55) | 0.826 | 0.74 (0.38–1.42) | 0.367 |
| sTIL status (manual) 1 | 0.81 (0.71–0.93) | 0.002 | 0.89 (0.77–1.02) | 0.090 |
| sTIL density (auto) 2 | 0.82 (0.72–0.93) | 0.002 | 0.87 (0.75–1.02) | 0.085 |