Table 2.

Multivariate analysis: ¹ Manual score is in increments of 10. ² sTIL Density is continuous but normalized to increments of 300 sTILs/mm².

Method	Overall Survival			Relapse Free Survival
	HR	95% CI	p-Value	HR	95% CI	p-Value
sTIL (manual) 1	0.79	0.68–0.91	0.001	0.84	0.71–0.99	0.037
Tumor Size	1.44	0.92–2.25	0.115	1.57	0.89–2.75	0.117
Age	2.96	1.52–5.77	0.001	1.72	0.88–3.35	0.112
Nodal status
1–3	1.92	1.20–3.07	0.007	2.23	1.26–3.95	0.006
≥4	4.52	2.61–7.84	<0.001	4.42	2.19–8.90	<0.001
Tumor type
Ductal vs. lobular	1.79	0.55–5.84	0.335	1.73	0.40–7.46	0.461
Ductal vs. other	0.91	0.55–1.51	0.718	0.74	0.38–1.45	0.384
sTIL density (auto) 2	0.81	0.72–0.92	0.001	0.86	0.75–1.00	0.047
Tumor Size	1.43	0.91–2.24	0.124	1.56	0.89–2.75	0.122
Age	3.02	1.55–5.90	0.001	1.76	0.90–3.43	0.099
Nodal status
1–3	1.91	1.19–3.07	0.007	2.22	1.25–3.92	0.006
≥4	4.12	2.40–7.08	<0.001	4.11	2.06–8.19	<0.001
Tumor type
Ductal vs. lobular	2.15	0.66–6.95	0.203	2.00	0.47–8.52	0.347
Ductal vs. other	0.89	0.54–1.48	0.664	0.74	0.38–1.44	0.375