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H2Sn are potential EDHFs. Both 3MST and eNOS are localized to endothelium. H2Sn produced by 3MST or by the chemical interaction between H2S and NO activate TRPA1 channels present in myoendothelial junctions to induce Ca2+ influx, which activates Ca2+-dependent K+ channels. The change in membrane potential is conducted via gap junction to hyperpolarize the smooth muscle plasma membrane.
