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Schematic representation of the effect of PP2A on Wnt signaling. PP2A can reverse p38-dependent phosphorylation of GSK3β, thus activating its kinase activity. Activation of GSK3β leads to the ubiquitination and degradation of β-Catenin. Adapted from “Wnt Beta-Catenin Signaling Pathway,” by BioRender.com (2021). Retrieved from https://app.biorender.com/biorender-templates, accessed on 11 May 2021.
