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. 2021 Jun 21;10(6):984. doi: 10.3390/antiox10060984

Figure 2.

Figure 2

(A–D) Effect of NERO on lipid peroxidation and oxidative stress. Lipid peroxidation and antioxidant status in the heart. Each column is mean ± SEM for eight rats in each group; columns do not share a common symbol (*, **) and differ significantly with each other (* p < 0.05 vs. normal control, ** p < 0.05 vs. DOX control). (E,F). Western immunoblot analysis and densitometric analysis for SOD1, SOD2, p67-phox, Nrf2, HO-1, and Keap-1. Values are expressed as mean ± SEM (n = 3); columns do not share a common symbol (*, **) and differ significantly with each other (* p < 0.05 vs. normal control, ** p < 0.05 vs. DOX control). MDA- malondialdehyde; SOD 1- superoxide dismutase 1; SOD 2- superoxide dismutase 2; HO-1-heme oxygenase-1; GSH-reduced glutathione; Nrf 2- Nuclear factor erythroid 2-related factor 2; NOR-normal; NERO-nerolidol; DOX- doxorubicin; ND- rats administered with a single intraperitoneal dose of DOX and orally treated with NERO.