Table 1.
Comparison of MICA allele frequencies between Taiwanese normal healthy controls and AS patients.
| MICA Allele | Estimated Frequency Trend Test | Logistic Regression | Logistic Regression Adjusted for Sex | ||||
|---|---|---|---|---|---|---|---|
| AS(2N = 1790) | Control (2N = 1792) | p Value | PFDR Value | OR (95% CI) | PFDR Value | OR (95% CI) | |
| MICA*019:01 | 765 (42.74%) | 157 (8.76%) | <0.00001 | 1.91×10−115 | 14.86 (11.80–18.71) | 2.25 × 10−115 | 14.90 (11.83–18.77) |
| MICA*008:01:01 | 332 (18.55%) | 510 (28.46%) | 2.0 × 10−12 | 1.4×10−11 | 0.57 (0.48–0.66) | 8.98 × 10−12 | 0.56 (0.48–0.66) |
| MICA*010:01 | 192 (10.73%) | 287 (16.02%) | 1.86 × 10−6 | 4.77×10−6 | 0.62 (0.50–0.75) | 4.50 × 10−6 | 0.61 (0.50–0.75) |
| MICA*002:01 | 190 (10.61%) | 376 (20.98%) | 3.82 × 10−17 | 8.05×10−16 | 0.45 (0.37–0.54) | 7.33 × 10−16 | 0.44 (0.37–0.54) |
| MICA*004 | 73 (4.08%) | 134 (7.48%) | 1.70 × 10−5 | 4.06×10−5 | 0.53 (0.40–0.71) | 4.98 × 10−5 | 0.54 (0.40–0.72) |
| MICA*012:01 | 55 (3.07%) | 144 (8.04%) | 1.49 × 10−10 | 1.92×10−9 | 0.37 (0.27–0.51) | 2.11 × 10−9 | 0.37 (0.27–0.51) |
| MICA*045 | 51 (2.85%) | 62 (3.46%) | 0.343 | 0.334 | 0.82 (0.57–1.19) | 0.360 | 0.83 (0.57–1.20) |
| MICA*033 | 39 (2.18%) | 2 (0.11%) | 1.17 × 10−8 | 6.46×10−5 | 19.36 (4.66–80.37) | 6.71 × 10−5 | 19.23 (4.63–79.86) |
| MICA*007:01 | 26 (1.45%) | 19 (1.06%) | 0.291 | 0.336 | 1.38 (0.76–2.51) | 0.360 | 1.38 (0.76–2.51) |
| MICA*018:01 | 5 (0.28%) | 4 (0.22%) | 0.738 | 0.738 | 1.25 (0.34–4.68) | 0.784 | 1.20 (0.32–4.51) |
| others | 62 (3.46%) | 97 (5.41%) | |||||