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. 2021 Jun 16;10(6):1512. doi: 10.3390/cells10061512

Figure 5.

Figure 5

Summary of the molecular signaling of ABHD4-regulating RNA panel in ACS based on putative interactions: (A) ABHD4 interacting with both hsa-miRNA-221 and hsa-miRNA-197 as retrieved from miRWalk database, (B) Mechanistic signaling of ABHD4-regulating RNA panel in ACS. Based on the interaction between ABHD4 and retrieved RNAs network, we hypothesized that down-regulation of FENDRR lncRNA in ischemic heart results in the release of free miR-197 with subsequent downregulation of miR-221 accompanied with the activation of ABHD4.