Table 1.
Identification results of differential metabolites and their change trends
| No. | RT(min) | m/z | Formula | Metabolite | VIP | M vs. C | Y vs. M | CL vs. M | CM vs. M | CH vs. M |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 5.5875 | 898.7862 | C57H100O6 | TG(18:2/18:1/18:2) | 2.75 | ↑** | – | – | ↓# | ↓## |
| 2 | 8.9231 | 931.7526 | C55H92O6 | TG(20:4/14:0/18:3) | 2.55 | ↑** | – | – | – | – |
| 3 | 8.4467 | 925.7098 | C48H92NO8P | PC(24:1/16:1) | 2.54 | ↑** | – | – | ↓# | – |
| 4 | 2.6081 | 496.3364 | C50H94NO8P | PC(24:1/18:2) | 2.43 | ↑** | – | – | ↓## | ↓# |
| 5 | 9.0509 | 264.9627 | C41H82NO8P | PC(15:0/18:0) | 2.29 | ↑** | – | – | ↓# | – |
| 6 | 9.0937 | 326.9082 | C54H102NO8P | PC(24:1/22:2) | 2.70 | ↑** | ↓## | – | ↓## | ↓## |
| 7 | 1.8681 | 516.3129 | C24H48NO7P | LPC(16:1/0:0) | 2.35 | ↑** | – | – | – | – |
| 8 | 2.0389 | 610.3188 | C30H54NO7P | LPC(22:4/0:0) | 2.56 | ↑** | – | ↓# | – | – |
| 9 | 2.0460 | 542.3279 | C26H50NO7P | LPC(18:2/0:0) | 2.37 | ↑** | – | ↓## | – | – |
| 10 | 4.1085 | 273.6606 | C26H54NO7P | LPC(18:0/0:0) | 2.09 | ↑* | – | – | – | – |
| 11 | 9.3573 | 416.2983 | C45H76NO8P | PE(18:3/22:4) | 2.15 | ↑** | – | – | ↓# | ↓# |
| 12 | 9.0937 | 326.9082 | C53H102NO8P | PE(24:1/24:1) | 2.43 | ↑* | – | – | ↓## | ↓## |
| 13 | 9.0230 | 376.8943 | C51H90O2 | CE(24:1) | 2.60 | ↑* | ↓# | – | ↓## | ↓## |
C, control group; M, model group; Y, benzbromarone group; CL, low dosage group; CM, medium dosage group; CH, high dosage group; **, p < 0.01 vs. control group. *, p < 0.05 vs. control group; ##, p < 0.01 vs. model group; #, p < 0.05 vs. model group. (↑): up-regulated and (↓): down-regulated. (−):no statistically significant difference