Table 1.
Experimental design to swell and impregnate PLA with ketoprofen using scCO2.
| Fixed Parameters | Varying Parameters | Response | |||
|---|---|---|---|---|---|
| Swelling study | CO2 flow until target pressure Contact time Depressurization rate Amount of PLA |
10 g/min 0.5 h 100 bar/min 0.3 g |
Pressure Temperature |
100, 250, 400 bar 35, 55, 75 °C |
Swelling |
| SSI | CO2 flow until target pressure Contact time Depressurization rate Amount of PLA Amount of KET |
10 g/min 2 h 100 bar/min 0.3 g Saturation |
Pressure Temperature |
100, 250, 400 bar 35, 55, 75 °C |
Swelling Drug loading |