. 2021 Jun 16;10(6):540. doi: 10.3390/biology10060540

Table 1.

Inclusion and exclusion criteria.

Inclusion Criteria	Exclusion Criteria
1. Female participants aged 20–75 years who were diagnosed with OAB for more than 3 months. 2. OAB symptoms included daytime frequency of micturition ≥ 8 times, and nocturia, urgency or urgency incontinence ≥ 1 times. 3. Patients could understand and follow the instructions and were able to complete the questionnaire. 4. Patients with OAB symptom who did not take antimuscarinic or ß3 agonist. 5. OAB patient with antimuscarinic or ß3 agonist treatment could also be included after 3 months of medication withdrawal 6. Signature of informed consent form.	1. Urinary tract infection detected at screening, and recurrent for urinary tract infections more than 3 episodes in the past 3 months. 2. Neuropathic diseases. 3. Lower urinary tract surgery within last 6 months. 4. Significant bladder outflow obstruction. 5. Drug or nondrug treatments of OAB in the previous 3 months. 6. History of urolithiasis or urologic cancer. 7. Gross hematuria. 8. Severe cardiopulmonary disease, coagulopathy, liver or renal dysfunction. 9. Previous pelvic radiation therapy. 10. Women with pregnancy or within six months of childbearing.

Inclusion Criteria

Exclusion Criteria

1. Female participants aged 20–75 years who were diagnosed with OAB for more than 3 months.
2. OAB symptoms included daytime frequency of micturition ≥ 8 times, and nocturia, urgency or urgency incontinence ≥ 1 times.
3. Patients could understand and follow the instructions and were able to complete the questionnaire.
4. Patients with OAB symptom who did not take antimuscarinic or ß3 agonist.
5. OAB patient with antimuscarinic or ß3 agonist treatment could also be included after 3 months of medication withdrawal
6. Signature of informed consent form.

1. Urinary tract infection detected at screening, and recurrent for urinary tract infections more than 3 episodes in the past 3 months.
2. Neuropathic diseases.
3. Lower urinary tract surgery within last 6 months.
4. Significant bladder outflow obstruction.
5. Drug or nondrug treatments of OAB in the previous 3 months.
6. History of urolithiasis or urologic cancer.
7. Gross hematuria.
8. Severe cardiopulmonary disease, coagulopathy, liver or renal dysfunction.
9. Previous pelvic radiation therapy.
10. Women with pregnancy or within six months of childbearing.

Note: OAB, overactive bladder.