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The USP7–MDM2–p53 axis. USP7 deubiquitinates both p53 and MDM2 but has stronger affinity for MDM2. MDM2 performs ubiquitination of p53 and self-ubiquitination. P53 promotes the expression of its target genes, including MDM2. MDMX can heterodimerize with MDM2 to facilitate p53 ubiquitination or directly block p53 action.
