Table 1.

Polyphenols as TopoII poisons [9].

Polyphenol	Proposed Mechanisms of Action
EGCG EGC	Presence of -OH groups at C3′ and C5′ increases the redox activity of the B ring and allows the compound as a redox-dependent poison.
Kaempferol Quercetin	Presence of -OH groups at C4′ of the B ring which makes the compound acts like a traditional, redox-independent poison. Aromatic and planar structure of the C ring with a C4-keto group that allows the formation of a proposed pseudo ring with the C5-OH.
Myricetin	Presence of -OH groups at C3′ and C5′ increases the redox activity of the B ring and allows the compound as a redox-dependent poison. Presence of -OH groups at C4′ of the B ring which makes the compound acts like a traditional, redox-independent poison. Aromatic and planar structure of the C ring with a C4-keto group that allows the formation of a proposed pseudo ring with the C5-OH.