Table 3.

Effect of polyphenols on the anti-cancer activity of etoposide—in vivo studies.

Polyphenol	In Vivo Model	Dose of Polyphenol	Dose of Etoposide	Interaction with Etoposide	Ref.
Curcumin	Brown Norway rats with acute myeloid leukemia (BNML)	100 and 200 mg/kg	50 mg/kg	enhances the tumor reduction and induces apoptosis of BNML cells more efficiently than etoposide alone	[30]
	BALB/c mice bearing SGC7901 cells xenografts	1 mg	5 mg	decreases tumor volume in comparison to mice treated only with etoposide	[41]
	BNML rats	200 mg/kg	50 mg/kg	decreases the number of promyelocytes to the normal values occurring in healthy individuals; increases the percentage of the normal precursors of granulocytes and erythrocytes	[63]
(−)-Epicatechin	Brown Norway rats with acute myeloid leukemia (BNML)	40 mg/kg	50 mg/kg	increases the in vivo apoptotic effect of etoposide; increases the oxidative stress induced by etoposide by a decrease in SOD activity	[64]
Quercetin	Bone marrow cells from BN/CrlCmd rats	100 mg/kg	50 mg/kg	reduces oxidative DNA damage; protects against a decrease in the percentage of myeloid precursors and erythroid nucleated cells caused by etoposide	[59]