Figure 3.

Top5 altered metabolites in PH rat models. Bar graph of metabolites discriminating chronic-hypoxia rats (CH) models from normoxia rats (Nx) and monocrotaline (MCT) rats from vehicle rats (Vhcl) (Mann–Whitney test). (A). In plasma. (B). In right ventricle. (C). In left ventricle. Significance versus the respective control group (Mann–Whitney test): * p ≤ 0.05. ** p ≤ 0.01. *** p ≤ 0.001. Reader’s note: due to specific matrix effects, intensities in plasma and heart tissues are not comparable.