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. 2021 Jun 21;10(6):1559. doi: 10.3390/cells10061559

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metabolomic pathways mainly altered on CH-PH and MCT-PH rats. IDO: Indoleamine 2,3-Dioxygenase. TPH: Tryptophan hydroxylase. NOS: Nitric oxide synthase. Main impacted pathways in: (A) hypoxia rat model (A1: Arginine metabolic pathway, A2: Pyrimidine metabolic pathway, A3: Tryptophan metabolic pathway and A4: Purine metabolic pathway) and (B) MCT rat model (B1: Arginine metabolic pathway, B2: Pyrimidine metabolic pathway, B3: Tryptophan metabolic pathway and B4: Purine metabolic pathway). Green color: metabolites altered in both heart and plasma samples. Red color: metabolites altered only in heart samples. Blue color: metabolites altered only in plasma samples.