Table 1.
Echocardiography and catheterization measures on CH-PH and MCT-PH rats and their respective controls.
| Normoxia (Nx) | CH-PH | Nx vs. CH-PH | Vehicle | MCT-PH | Vhcl vs. MCT-PH | CH-PH vs. MCT-PH | ||
|---|---|---|---|---|---|---|---|---|
| (Vhcl) | ||||||||
| Morphometric | Body weight (g) | 259.8 ± 19.14 | 228 ± 19.22 | ** | 277.64 ± 22.82 | 249.27 ± 56.16 | ns | * |
| Parameters | RV weight (mg) | 173.6 ± 13.43 | 381.2 ± 81.79 | *** | 154.33 ± 17.4 | 268.27 ± 70.6 | *** | ** |
| LV + Septum weight (mg) | 603.3 ± 56.57 | 606.6 ± 64.14 | ns | 595.2 ± 37.4 | 554.73 ± 111.69 | ns | ns | |
| Fulton’s index | 0.29 ± 0.02 | 0.63 ± 0.12 | *** | 0.26 ± 0.03 | 0.49 ± 0.11 | *** | * | |
| TAPSE (mm) | 0.24 ± 0.05 | 0.26 ± 0.06 | ns | 0.3 ± 0.01 | 0.23 ± 0.04 | ** | ns | |
| RV Parameters | VTI-PA | 6.38 ± 0.62 | 5.65 ± 0.56 | * | 6.63 ± 0.76 | 4.29 ± 1.21 | *** | * |
| PA diam (mm) | 2.44 ± 0.15 | 2.26 ± 0.24 | ns | 2.4 ± 0.2 | 2.29 ± 0.28 | ns | ns | |
| PAAT (ms) | 34.3 ± 3.56 | 27 ± 3.6 | ** | 32.43 ± 1.71 | 23.44 ± 4.05 | *** | ns | |
| RVET (ms) | 78.6 ± 5.88 | 80.7 ± 5.98 | ns | 80.71 ± 5.63 | 76.22 ± 7.04 | ns | ns | |
| Cycle length (ms) | 159.1 ± 10.32 | 160.2 ± 8.6 | ns | 154.5 ± 21.21 | 170.44 ± 16.05 | ns | ns | |
| RV free wall thickness (mm) | 1.12 ± 0.16 | 1.36 ± 0.23 | * | 0.99 ± 0.18 | 1.33 ± 0.23 | ** | ns | |
| RV_FS (%) | 47.94 ± 8.16 | 39.02 ± 11.18 | ns | 44.13 ± 6.66 | 32.65 ± 14.76 | ns | ns | |
| VTI-Ao | 5.9 ± 0.92 | 5.57 ± 0.72 | ns | 8.16 ± 0.91 | 5.88 ± 1.29 | *** | ns | |
| LV Parameters | LV free wall thickness (mm) | 1.53 ± 0.24 | 1.85 ± 0.24 | * | 1.64 ± 0.17 | 1.48 ± 0.17 | ns | ** |
| LV_FS (%) | 49.16 ± 8.79 | 48.11 ± 8.21 | ns | 41.47 ± 6.8 | 48.89 ± 8.13 | ns | ns | |
| Closed Chest Heart | RVS.P (mmHg) | 34.1 ± 6.7 | 68.26 ± 10.83 | *** | 32.83 ± 4.01 | 89.46 ± 26.02 | *** | * |
| Catheterization | HR (beat/min) | 346.6 ± 48.09 | 376.4 ± 43.29 | ns | 346.62 ± 43.26 | 333.38 ± 39.75 | ns | ns |
| MaxdPdt (mmHg/s) | 2629.61 ± 1444.89 | 4448.63 ± 1990.74 | * | 3422.57 ± 627.95 | 6913.86 ± 1317.87 | *** | * | |
| MindPdt (mmHg/s) | −1095.54 ± 428.09 | −2265.96 ± 921.23 | ** | −1385.43 ± 306.83 | −2194.57 ± 568.54 | *** | ns | |
| CO (ml/min) | 81.55 ± 3.82 | 72.56 ± 16.57 | ns | 85.35 ± 14.13 | 53 ± 18.84 | *** | * | |
| PVR | 0.44 ± 0.06 | 0.98 ± 0.19 | *** | 0.4 ± 0.09 | 1.97 ± 1.14 | *** | * | |
| EDP (mmHg) | 4.92 ± 3.02 | 12.79 ± 11.53 | * | 4.68 ± 1.96 | 17.34 ± 7.72 | *** | ns | |
| RV Contractility index (s−1) | 123.9 ± 26.46 | 121.7 ± 13.63 | ns | 122.08 ± 28.22 | 75.25 ± 14.7 | *** | *** |
Data are presented as mean ± standard deviation. t-tests were used after verification of normal distribution of values (Shapiro–Wilk normality test). Significance: * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001. ns: Non-significant. pulmonary artery acceleration time (PAAT, ms), pulmonary artery and aorta velocity time integral (VTI-PA and VTI-Ao), Tricuspid annular plane systolic excursion (TAPSE; mm), RV ejection time (RVET; ms), Cycle length (ms), RV and LV fractional shortening (RV FS and LV FS; %), right ventricle systolic pressure (RVS.P, mmHg), heart rate (HR, bpm), cardiac output (CO, mL/min), pulmonary vascular resistance (PVR, WU), end diastolic pressure (EDP, mmHg).