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. 2021 Jun 21;10(6):1559. doi: 10.3390/cells10061559

Table 3.

Spearman correlations between metabolites from arginine, pyrimidine, purine, and tryptophan and five catheterization and echocardiography parameters. RT: Retention time in chromatographic separation. PL: Plasma. RV: Right ventricle. LV: LEFT ventricle. Significance: * p ≤ 0.05 ** p ≤ 0.01 *** p ≤ 0.001. ns: non-significant. nr: Not detected or not robust feature.

SPEARMAN CH-PH vs. Normoxia SPEARMAN MCT-PH vs. Vehicle
RVS.P RV Weight Fulton’s Index PVR PAAT RVS.P RV weight Fulton’s Index PVR PAAT
Name m/z RT (min) Ion PL RV LV PL RV LV PL RV LV PL RV LV PL RV LV PL RV LV PL RV LV PL RV LV PL RV LV PL RV LV
Arginine 175.1187 0.7 [M+H]+ −0.51 * −0.53 * −0.74 *** −0.48 * ns −0.72 *** ns ns −0.63 ** ns ns −0.81 *** ns ns 0.51 * −0.54 * −0.54 ** ns ns −0.42 * ns −0.53 ** −0.58 ** ns −0.46 * −0.51 * ns 0.66 *** 0.43 * ns
Creatine 130.0623 7.6 [M−H]− −0.66 ** −0.76 *** −0.81 *** −0.7 *** −0.71 *** −0.85 *** −0.67 ** −0.64 ** −0.79 *** −0.51 * −0.76 *** −0.86 *** 0.52 * 0.69 *** 0.75 *** ns −0.44 * −0.66 ** ns −0.58 ** −0.7 *** ns −0.61 ** −0.73 *** ns −0.47 * −0.75 *** ns ns 0.7 ***
Guanidinoacetate 116.0466 8.3 [M−H]− 0.69 *** 0.79 *** 0.77 *** 0.71 *** 0.87 *** 0.78 *** 0.7 *** 0.85 *** 0.73 *** 0.65 ** 0.83 *** 0.82 *** ns −0.76 *** −0.75 *** ns 0.47 * ns ns 0.63 *** 0.4 * ns 0.47 * ns ns 0.57 ** ns 0.44 * ns ns
Aspartate 132.0302 8.20 [M−H]− 0.54 * 0.55 * 0.54 * 0.69 *** 0.56 * 0.45 * 0.59 ** 0.54 * 0.47 * 0.73 *** 0.51 * ns −0.5 * ns ns ns 0.56 ** ns ns 0.4 * ns ns ns ns ns 0.46 * ns ns ns 0.48 *
Fumarate 115.0035 8.8 [M−H]− 0.51 * ns 0.56 ** 0.47 * 0.45 * 0.61 ** ns ns 0.55 * 0.6 ** 0.55 * 0.75 *** ns ns −0.57 ** ns 0.64 ** ns ns 0.53 ** ns ns 0.53 ** ns ns 0.66 ** ns ns ns ns
Oxoglutarate 145.0140 8.6 [M−H]− 0.66 ** ns ns 0.69 ** −0.46 * ns 0.64 ** −0.5 * ns 0.76 *** −0.59 ** ns −0.52 * 0.44 * ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns
N-acetyl-glutamate 188.0563 8 [M−H]− 0.53 * ns ns 0.5 * ns ns ns −0.52 * ns 0.48 * −0.48 * ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns
Spermidine 146.1651 0.6 [M+H]+ ns 0.52 * 0.79 *** 0.5 * 0.6 ** 0.75 *** ns 0.57 ** 0.82 *** 0.6 ** 0.57 * 0.83 *** ns ns −0.59 ** ns 0.6 ** ns 0.44 * 0.5 * ns 0.43 * 0.64 *** ns ns 0.66 ** ns ns −0.64 *** −0.42 *
Acetyl-spermidine 188.1755 0.7 [M+H]+ ns 0.74 *** 0.73 *** ns 0.82 *** 0.74 *** ns 0.79 *** 0.78 *** ns 0.8 *** 0.84 *** ns −0.66 ** −0.68 ** ns 0.63 ** 0.61 ** ns 0.69 *** 0.54 ** ns 0.83 *** 0.77 *** ns 0.69 *** 0.69 *** ns −0.78 *** −0.68 ***
Glutamine 145.0616 7.7 [M−H]− 0.70 *** ns ns 0.6 ** ns ns 0.74 *** ns ns 0.6 ** ns ns −0.69 *** ns ns ns ns ns ns −0.44 * ns ns −0.58 ** ns ns −0.48 * ns ns 0.48 * ns
Citrulline 174.088 8.1 [M−H]− ns ns −0.52 * ns ns ns ns ns ns ns ns ns ns ns 0.46 * ns ns ns ns ns ns ns ns −0.51 ** ns ns ns ns ns 0.46 *
Guanidinobutanoate 146.0922 0.9 [M+H]+ 0.82 *** ns ns 0.85 *** ns ns 0.78 *** 0.46 * 0.57 * 0.85 *** ns ns −0.55 * ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns
Putrescine 89.1072 0.7 [M+H]+ ns 0.80 *** 0.78 *** ns 0.76 *** 0.69 *** ns 0.76 *** 0.79 *** ns 0.82 *** 0.79 *** ns −0.7 *** −0.72 *** ns 0.56 ** ns ns 0.56 ** ns ns 0.72 *** ns ns 0.58 ** ns ns −0.47 * ns
Creatinine 112.0516 3.5 [M−H]− 0.62 ** ns ns 0.6 ** ns ns 0.7 *** ns ns 0.73 *** ns ns −0.53 * ns ns ns ns ns 0.46 * ns ns 0.55 ** ns ns ns ns ns −0.54 ** ns ns
Ornithine 131.083 9.6 [M−H]− 0.56 * ns ns 0.5 * ns ns 0.69 *** ns ns 0.65 ** ns ns −0.49 * ns ns ns 0.77 *** ns ns 0.75 *** ns ns 0.64 *** ns ns 0.81 *** ns ns −0.46 * ns
Aminobutanoate 102.0561 8.4 [M−H]− ns −0.48 * ns ns ns −0.54 * ns ns −0.56 * ns −0.49 * ns ns 0.45 * 0.59 ** ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns
Glutamate 146.0455 8.3 [M−H]− ns ns ns ns ns −0.55 * ns ns −0.57 ** ns ns ns ns ns 0.59 ** ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns
Trans-4-L-hydroxy-proline 130.0509 7.8 [M−H]− ns ns ns ns ns ns ns ns ns ns ns ns ns ns 0.68 ** ns ns ns ns ns ns −0.45 * ns ns ns ns ns ns ns 0.43 *
Orotate 155.0097 4.8 [M−H]− 0.69 *** 0.81 *** 0.75 *** 0.7 *** 0.9 *** 0.76 *** 0.57 * 0.82 *** 0.73 *** 0.8 *** 0.9 *** 0.83 *** −0.65 ** −0.72 *** −0.63 ** ns 0.58 ** ns ns ns ns ns 0.54 ** ns ns 0.64 ** ns ns −0.46 * ns
Cytosine 112.0503 0.9 [M+H]+ 0.78 *** 0.53 * 0.55 * 0.83 *** 0.67 ** 0.51 * 0.56 * 0.55 * ns 0.85 *** 0.62 ** 0.5 * −0.52 * −0.68 ** ns ns ns ns ns ns ns ns ns ns ns 0.46 * ns ns ns ns
Deoxycytidine 228.0975 0.9 [M+H]+ 0.80 *** 0.5 * 0.71 *** 0.87 *** 0.61 ** 0.71 *** 0.63 ** 0.46 * 0.52 * 0.89 *** 0.66 ** 0.73 *** −0.59 ** ns ns ns ns −0.52 * ns ns ns ns ns ns ns ns ns ns ns ns
Deoxyuridine 227.0672 2.8 [M−H]− 0.74 *** ns 0.47 * 0.69 *** ns 0.48 * 0.68 ** ns ns 0.8 *** ns 0.47 * ns ns ns ns 0.6 ** ns ns 0.69 *** 0.54 ** ns 0.62 *** 0.5 * ns 0.59 ** ns ns −0.49 * ns
Pseudouridine 243.0619 5.8 [M−H]− 0.56 * 0.51 * 0.51 * 0.59 ** 0.58 ** 0.49 * 0.65 ** 0.5 * ns 0.68 ** 0.61 ** 0.52 * −0.49 * −0.46 * ns ns 0.7 *** ns 0.41 * 0.48 * ns 0.45 * 0.62 *** 0.49* ns 0.67 *** ns ns −0.67 *** ns
Uridine 243.0618 3.8 [M−H]− 0.57 ** ns ns 0.48 * ns ns ns ns ns 0.59 ** ns ns ns ns ns ns 0.5 * ns ns 0.66 *** ns ns 0.62 *** ns ns 0.46 * ns ns ns ns
Thymidine 243.0971 1.9 [M+H]+ 0.74 *** ns ns 0.78 *** ns ns 0.63 ** ns ns 0.81 *** ns ns −0.57 ** ns ns ns 0.6 ** ns 0.45 * ns ns 0.61 ** 0.47 * ns ns 0.57 ** ns −0.46 * −0.63 *** ns
Thymine 125.036 2.3 [M−H]− 0.65 ** ns ns 0.66 ** ns ns 0.64 ** ns ns 0.58 * ns ns ns ns ns 0.46 * 0.66 *** ns 0.47 * 0.4 * ns 0.62 *** 0.58 ** ns ns 0.62 ** ns −0.58 ** −0.64 *** ns
Uracil 111.0198 2.9 [M−H]− 0.48 * ns 0.61 ** 0.48 * ns 0.54 * ns ns 0.45 * 0.51 * ns 0.5 * ns ns ns ns 0.67 *** ns ns 0.56 ** ns 0.45 * 0.53 ** ns ns 0.71 *** ns −0.62 ** −0.58 ** ns
5-methyldeoxycytidine 242.1132 1 [M+H]+ ns 0.45 * 0.6 ** ns 0.46 * 0.52 * ns 0.55 * 0.52 * ns 0.46 * 0.6 ** ns ns −0.49 * 0.55 ** 0.63 ** ns ns 0.42 * ns ns 0.42 * ns ns 0.73 *** ns ns −0.59 ** ns
Acetyl-cytidine 286.103 2 [M+H]+ ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns 0.51 * 0.6 ** ns ns ns ns ns 0.59 ** 0.46 * 0.53 * 0.66 ** ns −0.49 * −0.72 *** −0.46 *
Dihydrouracil 115.0502 0.8 [M+H]+ 0.62 ** −0.52 * −0.46 * 0.69 ** −0.56 * −0.61 ** 0.47 * −0.49 * −0.59 ** 0.65 ** −0.57 * −0.56 * ns 0.79 *** ns 0.6 ** −0.45 * ns 0.47 * ns ns 0.65 *** ns ns 0.53 * −0.51 * ns −0.55 ** ns ns
Dihydroorotate 157.0253 5.5 [M−H]− ns −0.52 * ns ns −0.56 * ns ns −0.49 * ns ns −0.57 * ns ns 0.79 *** ns 0.53 * −0.45 * ns 0.42 * ns ns 0.51 ** ns ns 0.56 ** −0.51 * ns −0.75 *** ns ns
Allantoin 157.0364 7.2 [M−H]− 0.69 *** 0.53 * 0.80 *** 0.68 ** 0.58 ** 0.81 *** 0.5 * 0.5 * 0.74 *** 0.72 *** 0.55 * 0.85 *** ns ns −0.61 ** ns 0.64 ** 0.53 * ns ns ns ns 0.49 * 0.57 ** ns 0.71 *** 0.61 ** −0.55 ** −0.66 *** −0.46 *
7-methyl-guanine 164.0579 3.5 [M−H]− ns ns 0.68 ** 0.45 * 0.51 * 0.67 ** 0.57 * 0.48 * 0.52 * 0.49 * ns 0.71 *** ns ns −0.53 * ns 0.65 *** 0.43 * ns 0.44 * ns ns 0.58 ** 0.53 ** ns 0.63 ** ns ns −0.57 ** ns
Methyl-inosine 283.1033 1.7 [M+H]+ 0.65 ** ns ns 0.52 * ns ns ns ns ns 0.56 * ns ns ns ns ns ns 0.68 *** ns ns 0.41 * ns ns 0.49 * ns ns 0.66 ** ns ns −0.47 * ns
Inosine 269.0876 1.2 [M+H]+ nr ns −0.63 ** nr ns −0.7 *** nr ns −0.83 *** nr ns −0.65 ** nr ns 0.65 ** nr −0.58 ** ns nr −0.57 ** ns nr −0.65 *** ns nr −0.59 ** ns nr ns 0.46 *
Guanosine 282.0841 6 [M−H]− nr ns ns nr ns ns nr ns ns nr ns ns nr 0.57 ** ns nr ns ns nr −0.51 ** ns nr −0.57 ** ns nr ns −0.46 * nr 0.49 * ns
Xanthosine 283.0679 6.4 [M−H]− nr ns ns nr ns ns nr 0.46 * ns nr 0.51 * ns nr −0.46 * ns nr 0.51 * ns nr 0.52 ** ns nr 0.61 ** ns nr 0.52 * ns nr −0.65 *** ns
Xanthine 153.0405 1 [M+H]+ nr ns ns nr ns ns nr ns ns nr 0.49 * ns nr −0.51 * −0.46 * nr ns ns nr ns ns nr 0.39 * ns nr ns ns nr −0.51 * ns
Urate 169.0352 1 [M+H]+ ns ns ns ns ns 0.49 * ns ns 0.53 * ns ns 0.65 ** ns ns ns ns ns ns ns 0.46 * ns ns 0.51 ** ns ns ns ns ns −0.42 * ns
Adenine 136.0616 0.9 [M+H]+ nr −0.62 ** ns nr −0.54 * ns nr −0.59 ** ns nr ns ns nr 0.51 * ns nr ns ns nr ns ns nr ns ns nr ns ns nr ns ns
5’-AMP 348.0697 0.9 [M+H]+ nr −0.51 * ns nr −0.49 * ns nr ns ns nr −0.49 * ns nr 0.71 *** ns nr ns ns nr ns ns nr ns ns nr ns ns nr ns ns
Indole-propionate 188.0714 2.3 [M−H]− ns ns 0.5 * ns 0.49 * 0.58 ** ns ns 0.6 ** ns 0.47 * 0.67 ** ns ns −0.57 ** ns 0.49 * ns ns ns ns ns ns ns ns 0.49 * 0.46 * ns ns ns
Indolelactate 204.0664 2.8 [M−H]− −0.68 *** −0.49 * ns −0.64 ** ns ns −0.57 * ns ns −0.52 * ns ns 0.66 ** 0.48 * ns −0.43 * ns ns ns ns ns ns ns ns ns ns ns ns ns ns
Kynurenine 209.0918 1.9 [M+H]+ 0.63 ** ns 0.61 ** 0.7 *** ns 0.63 ** 0.64 ** ns 0.54 * 0.74 *** ns 0.69 ** ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns
Tryptophan 203.0822 4.5 [M−H]− ns ns 0.5 * ns ns 0.5 * ns ns 0.45 * ns ns 0.53 * ns ns −0.54 * ns 0.5 * ns −0.44 * ns ns −0.6 ** ns ns ns 0.49 * ns 0.58 ** ns ns
Tyrosine 182.0808 1.1 [M+H]+ ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns 0.64 ** 0.5 * ns 0.56 ** ns ns 0.48 * ns ns 0.68 *** 0.53 * 0.59 ** −0.46 * −0.56 ** ns
Phenylalanine 164.0714 3.2 [M−H]− −0.81 *** ns ns −0.8 *** ns ns −0.7 *** ns ns −0.76 *** ns ns 0.7 *** ns ns ns 0.53 * ns ns ns ns ns 0.43 * ns ns 0.48 * ns ns −0.58 ** ns
Acetyl-serotonin 219.1127 5.1 [M+H]+ ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns 0.44* ns −0.4 * 0.54 ** ns −0.50 ** 0.61 ** ns ns ns 0.45 * 0.65 *** ns ns
Serotonin 160.0755 1.5 [M+H−NH3]+ −0.58 ** nr nr −0.51 * nr nr −0.6 ** nr nr ns nr nr 0.52 * nr nr −0.44 * nr nr ns nr nr −0.42 * nr nr −0.44 * nr nr 0.71 *** nr nr
Xanthurenate 206.0447 4.1 [M+H]+ ns nr nr ns nr nr ns nr nr ns nr nr ns nr nr ns nr nr ns nr nr ns nr nr ns nr nr −0.48 * nr nr
Aminophenol 110.0598 1 [M+H]+ ns ns ns ns ns ns ns ns ns ns ns ns ns 0.54 * ns ns ns ns ns ns ns −0.49 * ns ns −0.47 * ns ns 0.56 ** ns ns
Kynurenate 190.0496 4.5 [M+H]+ ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns
N-acetyl-tryptophan 247.1074 6 [M+H]+ ns ns ns ns ns ns ns ns ns ns ns ns ns ns ns 0.72 *** ns ns 0.59 ** ns ns 0.5 ** ns ns 0.62 ** ns ns ns ns ns
Caption −0.6 < R or R > 0.6 −0.7 < R or R > 0.7 −0.8 < R or R > 0.8