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Schematic representation of NOX-induced ROS pathways leading to ECM remodeling during HCC development. NOXs isoforms are differently expressed in hepatic cells involved in NASH–fibrosis–HCC progression. Abbreviations: NADPH oxidase, NOX; hepatic stellate cell, HSC; Kupffer cell, KC; reactive oxygen species, ROS; damage-associated molecular patterns, DAMPs; extracellular matrix, ECM.
