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. 2021 Jun 18;10(6):976. doi: 10.3390/antiox10060976

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of baicalein and Fer-1 supplementation on the expression of COX-2, lipid peroxidation and GSH in the liver tissues of mice challenged with CCl₄. (A) Effect of baicalein supplementation on expression of ALOX12, SCD1, and COX-2 mRNAs in liver tissues. (B) Effect of baicalein supplementation on the levels of MDA in liver tissues. (C) Effect of baicalein supplementation on the levels of reduced GSH (shown as GSH) in liver tissues. (D) Effect of Fer-1 supplementation on the levels of MDA in liver tissues. (E) Effect of Fer-1 supplementation on the expression of COX-2 mRNA in liver tissues. All data are presented as mean ± SD (n = 6). ** p < 0.01, compared to the untreated control group, respectively; ^# p < 0.05 or ^## p < 0.01 compared to the CCl₄-only group. MDA: malondialdehyde; GSH: glutathione; Bai: baicalein.