Table 3.
Vascular function and hemostatic measurement.
| DAPT (CLPD+ASP) |
Monotherapy (CLPD) |
Monotherapy (ASP) |
p (DAPT vs. CLPD) |
p (DAPT vs. ASP) |
p (CLPD vs. ASP) |
|
|---|---|---|---|---|---|---|
| EndoPAT | ||||||
| RHI, % | 2.19 ± 0.68 | 2.11 ± 0.77 | 1.87 ± 0.72 | 0.479 | 0.023 | 0.045 |
| LnRHI | 0.74 ± 0.32 | 0.68 ± 0.37 | 0.55 ± 0.35 | 0.331 | 0.002 | 0.015 |
| Arterial stiffness indices | ||||||
| Brachial SBP, mmHg | 132.9 ± 17.3 | 130.0 ± 18.1 | 125.5 ± 19.6 | 0.559 | 0.152 | 0.386 |
| Brachial DBP, mmHg | 76.2 ± 10.3 | 74.2 ± 10.1 | 73.4 ± 11.0 | 0.491 | 0.346 | 0.773 |
| Brachial PP, mmHg | 56.0 ± 10.7 | 55.9 ± 12.0 | 52.1 ± 12.7 | 0.961 | 0.239 | 0.282 |
| Central SBP, mmHg | 138.7 ± 19.7 | 134.7 ± 20.7 | 130.4 ± 21.6 | 0.474 | 0.152 | 0.466 |
| Central DBP, mmHg | 76.2 ± 10.3 | 74.2 ± 10.1 | 73.4 ± 11.0 | 0.491 | 0.346 | 0.773 |
| Central PP, mmHg | 62.6 ± 14.0 | 60.5 ± 14.1 | 57.0 ± 13.9 | 0.597 | 0.159 | 0.377 |
| AI, % | 83.5 ± 12.2 | 81.6 ± 12.4 | 81.6 ± 11.6 | 0.583 | 0.570 | 1.000 |
| AI@75, % | 77.0 ± 11.7 | 75.4 ± 11.6 | 75.8 ± 11.1 | 0.602 | 0.690 | 0.893 |
| PWV (mean), m/sec | 15.9 ± 2.8 | 15.5 ± 2.8 | 15.2 ± 2.6 | 0.620 | 0.327 | 0.642 |
| Ankle-brachial index (mean) | 1.14 ± 0.07 | 1.12 ± 0.07 | 1.12 ± 0.08 | 0.565 | 0.344 | 0.662 |
| VerifyNow P2Y12 assay | ||||||
| PRU | 138 ± 77 | 130 ± 64 | 214 ± 50 | 0.178 | <0.001 | <0.001 |
| BASE | 218 ± 39 | 208 ± 35 | 206 ± 36 | 0.102 | 0.133 | 0.639 |
| Thromboelastography | ||||||
| R, minutes | 5.8 ± 1.3 | 5.5 ± 1.2 | 5.1 ± 1.1 | 0.379 | 0.017 | 0.037 |
| K, minutes | 1.9 ± 0.8 | 1.9 ± 0.7 | 1.6 ± 0.5 | 0.727 | 0.124 | 0.157 |
| Angle, degree | 61.4 ± 8.5 | 62.9 ± 9.0 | 65.2 ± 8.1 | 0.441 | 0.145 | 0.346 |
| MAthrombin, mm | 60.3 ± 5.9 | 59.9 ± 5.2 | 61.0 ± 5.2 | 0.748 | 0.603 | 0.388 |
| LY30, % | 1.2 ± 1.7 | 1.1 ± 1.7 | 1.4 ± 2.4 | 0.684 | 0.722 | 0.490 |
AI, augmentation index; ASP, aspirin; CLPD, clopidogrel; DAPT, dual antiplatelet therapy; DBP, diastolic blood pressure; PAT, peripheral arterial tonometry; PP, pulse pressure; PRU, P212 reaction unit; PWV, pulse wave velocity; RHI, reactive hyperemia index; SBP, systolic blood pressure.