Table 3.
Uptake values obtained from biodistribution studies with 68Ga-DOTA-MGS5 (0.2–0.5 MBq, 20 pmol peptide) at 5, 20, 60, and 90 min p.i. in female BALB/c mice; values expressed as % IA/g (mean ± SD, n = 3).
|
68Ga-DOTA-MGS5 % IA/g 5 min p.i. |
68Ga-DOTA-MGS5 % IA/g 20 min p.i. |
68Ga-DOTA-MGS5 % IA/g 60 min p.i. |
68Ga-DOTA-MGS5 % IA/g 90 min p.i. |
|
|---|---|---|---|---|
| organ | mean ± sd | mean ± sd | mean ± sd | mean ± sd |
| blood | 17.58 ± 3.01 | 6.76 ± 1.17 | 1.99 ± 0.22 | 0.94 ± 0.08 |
| lung | 8.51 ± 2.33 | 3.78 ± 0.53 | 1.10 ± 0.11 | 0.59 ± 0.10 |
| heart | 5.11 ± 0.07 | 2.24 ± 0.57 | 0.70 ± 0.16 | 0.35 ± 0.02 |
| muscle | 2.89 ± 0.18 | 1.03 ± 0.21 | 0.49 ± 0.19 | 0.18 ± 0.04 |
| spleen | 3.53 ± 0.43 | 1.70 ± 0.38 | 0.71 ± 0.05 | 0.69 ± 0.09 |
| intestine | 2.42 ± 0.21 | 1.22 ± 0.25 | 0.75 ± 0.17 | 0.62 ± 0.08 |
| liver | 5.02 ± 0.06 | 2.28 ± 0.31 | 1.21 ± 0.12 | 1.00 ± 0.06 |
| kidneys | 17.60 ± 2.79 | 8.41 ± 1.33 | 5.11 ± 0.33 | 4.60 ± 0.32 |
| pancreas | 4.03 ± 0.19 | 2.17 ± 0.16 | 1.50 ± 0.38 | 1.42 ± 0.30 |
| stomach | 6.63 ± 0.23 | 4.09 ± 0.98 | 4.63 ± 0.65 | 4.12 ± 0.30 |
| femur | 2.77 ± 0.34 | 1.75 ± 0.93 | 0.62 ± 0.09 | 0.55 ± 0.09 |