Table 3.
Associations between breast cancer risk factors and ER status in Kenyan breast cancer patients (N=838)
| ER+ N=582 | ER- N=256 | ER- vs. ER+ | ||||
|---|---|---|---|---|---|---|
| N | % | N | % | OR (95% CI)† | P† | |
| Age at diagnosis/year | ||||||
| 20–39 | 155 | 26.8 | 54 | 21.1 | 1.00 (Ref) | |
| 40–49 | 166 | 28.7 | 76 | 29.7 | 1.38 (0.82, 2.32) | 0.23 |
| 50–59 | 138 | 23.9 | 73 | 28.5 | 1.20 (0.51, 2.83) | 0.68 |
| ≥ 60 | 119 | 20.6 | 53 | 20.7 | 0.84 (0.30, 2.35) | 0.74 |
| Trend‡ | 0.995 (0.72, 1.39) | 0.98 | ||||
| BMI/ kg/m2 | ||||||
| Normal (< 25.0) | 136 | 29.8 | 74 | 34.6 | 1.00 (Ref) | |
| Overweight (25.0–29.9) | 185 | 40.5 | 79 | 36.9 | 0.77 (0.49, 1.21) | 0.26 |
| Obese (≥ 30.0) | 136 | 29.8 | 61 | 28.5 | 0.84 (0.51, 1.38) | 0.49 |
| Trend‡ | 0.92 (0.71, 1.18) | 0.49 | ||||
| Premenopausal: BMIa | ||||||
| Normal (< 25.0) | 89 | 34.6 | 41 | 39.8 | 1.00 (Ref) | |
| Overweight (25.0–29.9) | 102 | 39.7 | 30 | 29.1 | 0.58 (0.31, 1.10) | 0.09 |
| Obese (≥ 30.0) | 66 | 25.7 | 32 | 31.1 | 0.91 (0.46, 1.77) | 0.77 |
| Trend‡ | 0.93 (0.66, 1.31) | 0.69 | ||||
| Postmenopausal: BMIa | ||||||
| Normal (< 25.0) | 47 | 23.6 | 33 | 29.7 | 1.00 (Ref) | |
| Overweight (25.0–29.9) | 83 | 41.7 | 49 | 44.1 | 1.07 (0.55, 2.08) | 0.85 |
| Obese (≥ 30.0) | 69 | 34.7 | 29 | 26.1 | 0.77 (0.37, 1.61) | 0.49 |
| Trend‡ | 0.87 (0.61, 1.26) | 0.47 | ||||
| Age at menarche/year | ||||||
| ≤ 13 (9–13) | 141 | 25.4 | 57 | 23.2 | 1.00 (Ref) | |
| 14 | 139 | 25.0 | 71 | 28.9 | 1.57 (0.94, 2.61) | 0.083 |
| ≥ 15 (15–20) | 276 | 49.6 | 118 | 48.0 | 1.29 (0.81, 2.04) | 0.28 |
| Trend‡ | 1.10 (0.88, 1.37) | 0.41 | ||||
| Age at first pregnancy/year | ||||||
| < 20 | 130 | 22.9 | 86 | 34.1 | 1.00 (Ref) | |
| 20–24 | 253 | 44.5 | 108 | 42.9 | 0.71 (0.44, 1.15) | 0.16 |
| 25–29 | 115 | 20.2 | 35 | 13.9 | 0.58 (0.30, 1.11) | 0.10 |
| Nulliparousb or age ≥30 | 70 | 12.3 | 23 | 9.1 | 1.14 (0.48, 2.70) | 0.76 |
| Trend‡ | 0.92 (0.71, 1.20) | 0.54 | ||||
| Parity | ||||||
| Nulliparousb | 37 | 6.4 | 7 | 2.7 | 0.36 (0.10, 1.32) | 0.12 |
| Parous | 545 | 93.6 | 249 | 97.3 | 1.00 (Ref) | |
| Number of children | ||||||
| 1–2 | 171 | 31.4 | 55 | 22.1 | 1.00 (Ref) | |
| 3–4 | 217 | 39.8 | 90 | 36.1 | 1.43 (0.86, 2.36) | 0.16 |
| ≥ 5 | 157 | 28.8 | 104 | 41.8 | 2.03 (1.11, 3.72) | 0.021 |
| Trend‡ | 1.43 (1.05, 1.93) | 0.021 | ||||
| Cumulative breastfeeding duration/monthc | ||||||
| Q1: 1–< 39 | 152 | 28.8 | 39 | 16.2 | 1.00 (Ref) | |
| Q2: 39–< 62 | 127 | 24.1 | 65 | 27.0 | 2.38 (1.33, 4.24) | 0.0033 |
| Q3: 62–< 96 | 124 | 23.5 | 58 | 24.1 | 1.44 (0.74, 2.80) | 0.28 |
| Q4: ≥ 96 | 124 | 23.5 | 79 | 32.8 | 1.58 (0.76, 3.30) | 0.22 |
| Trend‡ | 1.10 (0.87, 1.39) | 0.43 | ||||
| Mean breastfeeding duration per child/month | ||||||
| < 12 | 84 | 15.9 | 36 | 14.9 | 1.00 (Ref) | |
| 12–23 | 277 | 52.6 | 130 | 53.9 | 1.10 (0.62, 1.94) | 0.74 |
| ≥ 24 | 166 | 31.5 | 75 | 31.1 | 1.25 (0.68, 2.30) | 0.48 |
| Trend‡ | 1.12 (0.83, 1.51) | 0.45 | ||||
| Age at first pregnancy and number of children | ||||||
| Age 25+ years, 1–3 births | 117 | 22.0 | 37 | 15.0 | 1.00 (Ref) | |
| Age < 25 years, 1–3 births | 173 | 32.6 | 71 | 28.9 | 1.20 (0.68, 2.12) | 0.53 |
| Age 25+ years, 4+ births | 34 | 6.4 | 15 | 6.1 | 1.47 (0.60, 3.61) | 0.40 |
| Age < 25 years, 4+ births | 207 | 39.0 | 123 | 50.0 | 1.69 (0.93, 3.05) | 0.085 |
| Trend‡ | 1.19 (0.99, 1.43) | 0.063 | ||||
| Number of children and cumulative breastfeeding duration | ||||||
| Nulliparous or ≤ 3 children and < 62 months | 265 | 47.0 | 89 | 35.9 | 1.00 (Ref) | |
| ≤ 3 children and ≥ 62 months | 56 | 9.9 | 23 | 9.3 | 1.09 (0.56, 2.09) | 0.81 |
| ≥ 4 children and < 62 months | 51 | 9.0 | 22 | 8.9 | 1.52 (0.74, 3.09) | 0.25 |
| ≥ 4 children and ≥ 62 months | 192 | 34.0 | 114 | 46.0 | 1.44 (0.89, 2.34) | 0.14 |
| Trend‡ | 1.14 (0.97, 1.33) | 0.12 | ||||
| Menopausal statusa | ||||||
| Premenopausal | 317 | 54.6 | 121 | 47.5 | 1.00 (Ref) | |
| Postmenopausal | 264 | 45.4 | 134 | 52.5 | 1.44 (0.74, 2.81) | 0.28 |
| Age at menopause/yeard | ||||||
| < 50 | 117 | 21.8 | 74 | 31.5 | 1.00 (Ref) | |
| > 50 | 102 | 19.0 | 40 | 17.0 | 0.73 (0.40, 1.36) | 0.32 |
† Point estimates and 95% confidence intervals were from multivariable models, adjusting for the same series of covariates (except where noticed): age at diagnosis, BMI, age at menarche, age at first pregnancy, number of children, mean breastfeeding duration per child, age at menopause, family history of breast cancer in first-degree female relative, occupation, education level, and location of facility. Estimates of numbers of children, cumulative and averaged breastfeeding duration, and combined age at first pregnancy and number of children were computed among parous women. ‡ Results were from the trend analysis using the categorical risk factor as a trend. aMultivariable modeling analysis without adjusting for age at menopause. bWomen who reported never pregnant, never gave birth, and had no child were grouped as “Nulliparous” in modeling analyses. c Multivariable modeling analysis without adjusting for mean breastfeeding duration per child. d Multivariable Modeling analysis was restricted to postmenopausal women. BMI, body mass index; CI, confidence interval; ER, estrogen receptor; OR, odds ratio; Q, quartile