Table 4.

Prognostic factors for progression-free survival

Variable	Univariate	Multivariate
	p value	p value	Hazard ratio	95% CI
VAFmean-change, ≥0/< 0	< 0.001	0.002	8.4	2.3–31.2
Age, high/low	0.52
Sex, male/female	0.26
Dose, 12 mg/8 mg	0.92
BCLC, C/B	0.20
TNM staging, 4b/3 or 4a	0.28
T, 4/3 or less	0.05
M, 1/0	0.50
N, 1/0	0.35
Main tumor size, high/low	0.95
AFP, high/low	0.96
AFP, decrease/increase	0.56
DCP, high/low	0.03	0.13	2.3	0.8–6.7
ALBI, G2/G1	0.41

CI confidence interval, VAF variant allele frequency, BCLC Barcelona Clinic Liver Cancer, TNM Tumor, Node, Metastasis, MVI macroscopic portal vein invasion, AFP alpha-fetoprotein, DCP des-gamma-carboxy pro-thrombin, ALBI albumin-bilirubin