Table 1.

Definitions of Percent Specific Binding Used in Radioimmunoprecipitation Assays

Assay		Percent specific binding definition
MYL-1501D	Total ADA	%B/T (no inhibitor) − %B/T (excess MYL-1501D)
	Insulin cross-reactive ADA	%B/T (no inhibitor) − %B/T (excess insulin)
	Drug-specific ADA	%B/T (excess IGlar) − %B/T (excess MYL-1501D)
IGlar	Total ADA	%B/T (no inhibitor) − %B/T (excess reference insulin glargine)
	Insulin cross-reactive ADA	%B/T (no inhibitor) − %B/T (excess insulin)
	Drug-specific ADA	%B/T (excess MYL-1501D) − %B/T (excess IGlar)

ADA antidrug antibodies, %B/T percentage of bound to total reactivity, IGlar insulin glargine