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. Author manuscript; available in PMC: 2022 Aug 28.
Published in final edited form as: Cancer Lett. 2021 May 24;514:79–89. doi: 10.1016/j.canlet.2021.05.011

Table 1.

Histological Phenotypes and Average Life Span of Mice

Group Genotype Histology Median
survival (week)
A0 p48-Cre; LSL-KRASG12D PanIN 46.79
A1 p48-Cre; LSL-KRASG12D; HMMRΔexon8-16/WT PanIN undefined
A2 p48-Cre; LSL-KRASG12D; HMMRΔexon8-16/Δexon8-16 PanIN 48.86
B0 p48-Cre; LSL-KRASG12D; p53lox/+ PDAC 23.93
B1 p48-Cre; LSL-KRASG12D; p53lox/+; HMMRΔexon8-16/WT PDAC 17.50
B2 p48-Cre; LSL-KRASG12D; p53lox/+; HMMRΔexon8-16/Δexon8-16 PDAC 15.41
C0 p48-Cre; LSL-KRASG12D; p53lox/lox PDAC 9.14
C1 p48-Cre; LSL-KRASG12D; p53lox/lox; HMMRΔexon8-16/WT PDAC 9.86
C2 p48-Cre; LSL-KRASG12D; p53lox/lox; HMMRΔexon8-16/Δexon8-16 PDAC 9.57
T0 RIP-Tag PNET 17.57
T1 RIP-Tag; HMMRΔexon8-16/WT PNET 16.14
T2 RIP-Tag; HMMRΔexon8-16/Δexon8-16 PNET 15.50