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. 2021 Jun 26;19:272. doi: 10.1186/s12967-021-02938-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — COVID-19 signature based on six selected immune factors. The graphs represent the proportion of immune factors secreted in response to SARS-CoV-2 peptides stimulation within the six variables immune signature associated to COVID-19: RANTES induced by NP Pool1; IFN-γ by Spike; IP-10 by Spike; IP-10 by NP Pool2; IL-2 by Spike, IL-2 by ORF3a. The different immune factors were measured by luminex assay in plasma collected after stimulating whole-blood with the different antigens. A Proportion of selected immune factors in COVID-19 patients. B Proportion of selected immune factors in NO-COVID-19 subjects. C Median proportion of selected immune factors in COVID-19 and NO-COVID-19 subjects. NP nucleoprotein, IL interleukin; IP interferon-γ inducible protein; IFN interferon; RANTES regulated on activation, normal T cell expressed and secreted