Table 2.
Multivariate Cox Regression Analysis of HDL-C Levels with Cause-Specific Mortality
| Model I HR (95% CI), P | Model II HR (95% CI), P | Model III HR (95% CI), P | |
|---|---|---|---|
| All-cause mortality | |||
| HDL-C (per 1mmol/L increment) | 1.07 (0.94, 1.23) 0.3116 | 0.92 (0.79, 1.06) 0.2376 | 1.01 (0.86, 1.19) 0.8903 |
| HDL-C groups | |||
| Q1 | 1.30 (1.11, 1.53) 0.0015 | 1.43 (1.21, 1.70) <0.0001 | 1.30 (1.09, 1.56) 0.0046 |
| Q2 | 1.20 (1.02, 1.42) 0.0322 | 1.26 (1.06, 1.49) 0.0084 | 1.19 (0.99, 1.43) 0.0612 |
| Q3 | 1.22 (1.03, 1.45) 0.0218 | 1.20 (1.01, 1.42) 0.0380 | 1.14 (0.95, 1.37) 0.1628 |
| Q4 | 1.0 | 1.0 | 1.0 |
| Q5 | 1.30 (1.10, 1.54) 0.0020 | 1.20 (1.01, 1.42) 0.0370 | 1.20 (1.00, 1.44) 0.0481 |
| P for trend | 0.334 | 0.002 | 0.113 |
| Cardiovascular mortality | |||
| HDL-C (per 1mmol/L increment) | 0.94 (0.71, 1.25) 0.6716 | 0.83 (0.61, 1.12) 0.2130 | 0.97 (0.70, 1.34) 0.8408 |
| HDL-C groups | |||
| Q1 | 1.28 (0.94, 1.75) 0.1207 | 1.38 (1.00, 1.89) 0.0503 | 1.22 (0.86, 1.74) 0.2686 |
| Q2 | 1.06 (0.76, 1.47) 0.7445 | 1.08 (0.78, 1.51) 0.6438 | 1.02 (0.71, 1.45) 0.9347 |
| Q3 | 1.11 (0.80, 1.56) 0.5259 | 1.08 (0.77, 1.51) 0.6608 | 0.99 (0.69, 1.43) 0.9746 |
| Q4 | 1.0 | 1.0 | 1.0 |
| Q5 | 1.07 (0.77, 1.50) 0.6892 | 1.00 (0.71, 1.39) 0.9802 | 1.01 (0.70, 1.46) 0.9460 |
| P for trend | 0.212 | 0.043 | 0.327 |
| Cancer mortality | |||
| HDL-C (per 1mmol/L increment) | 1.13 (0.82, 1.58) 0.4542 | 1.11 (0.79, 1.57) 0.5465 | 1.18 (0.81, 1.72) 0.3955 |
| HDL-C groups | |||
| Q1 | 1.31 (0.89, 1.92) 0.1770 | 1.32 (0.89, 1.96) 0.1710 | 1.15 (0.76, 1.75) 0.5021 |
| Q2 | 1.06 (0.70, 1.59) 0.7980 | 1.05 (0.69, 1.59) 0.8253 | 0.97 (0.63, 1.48) 0.8849 |
| Q3 | 1.23 (0.82, 1.85) 0.3212 | 1.19 (0.79, 1.79) 0.4066 | 1.02 (0.67, 1.56) 0.9345 |
| Q4 | 1.0 | 1.0 | 1.0 |
| Q5 | 1.19 (0.79, 1.79) 0.4024 | 1.15 (0.77, 1.73) 0.4938 | 1.05 (0.69, 1.61) 0.8227 |
| P for trend | 0.550 | 0.459 | 0.722 |
Notes: Data are HR (95% CI). Model I adjust for none. Model II adjust for age, gender, and body mass index. Model III adjust for age, gender, body mass index, race, education level, smoking, systolic blood pressure, estimated glomerular filtration rate, glycohemoglobin, total cholesterol, comorbidities (hypertension, cardiovascular disease, and cancer), and medicine use (antihypertensive drugs, hypoglycemic agents, lipid-lowering drugs, and antiplatelet drugs). Multivariate Cox regression was performed.
Abbreviations: HDL-C, high density lipoprotein cholesterol; HR, hazard ratio; CI, confidence interval; Q, quintiles.