Table 1.

Mature T-Cell and NK-Cell Neoplasm Based on the WHO 2016 Classification

Mature T-Cell and NK-Cell Neoplasms
Nodal  Peripheral T-cell lymphoma, NOS  Angioimmunoblastic T-cell lymphoma  Anaplastic large-cell lymphoma, ALK+  Anaplastic large-cell lymphoma, ALK−  Follicular T-cell lymphoma  Nodal peripheral T-cell lymphoma with TFH phenotype  Systemic EBV+ T-cell lymphoma of childhood  Hydroa vacciniforme-like lymphoproliferative disorder
Extranodal  Monomorphic epitheliotropic intestinal T-cell lymphoma  Indolent T-cell lymphoproliferative disorder of the GI tract  Breast implant-associated anaplastic large-cell lymphoma  Enteropathy-associated T-cell lymphoma  Extranodal NK-/T-cell lymphoma, nasal type  Chronic lymphoproliferative disorder of NK cells  Hepatosplenic T-cell lymphoma
Cutaneous  Sézary syndrome  Mycosis fungoides  Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma Primary cutaneous acral CD8+ T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Primary cutaneous CD30+ T-cell lymphoproliferative disorders Primary cutaneous anaplastic large cell lymphoma Primary cutaneous γδ T-cell lymphoma Lymphomatoid papulosis Primary cutaneous anaplastic large cell lymphoma
Leukemic form  Aggressive NK-cell leukemia  T-cell large granular lymphocytic leukemia  T-cell prolymphocytic leukemia  Adult T-cell leukemia/lymphoma

Note: Data based on the WHO 2016 classification data from Swerdlow et al.³

Abbreviations: GI, gastro-intestinal; NK, natural killer; NOS, not otherwise specified; ALK, anaplastic lymphoma kinase; TFH, T follicular helper; EBV, Epstein Barr virus.