Fig. 1.

CONSORT diagram of subject flow through the study. Datasets of n = 44 patients (n = 22 of whom later received Naltrexone [NTX] in addition to intensified withdrawal treatment [IWT]) with complete baseline imaging data and complete follow-up data were included in current analyses. Datasets of other patients with incomplete baseline fMRI data or incomplete follow-up data and datasets of the healthy control sample were not included in current analyses. These data are reported in Bach et al. [6]