Table 2.
Uni- and multivariable survival analyses of patients with SB-NEN in The Netherlands
| Risk factors | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Diagnosis year | ||||
| 2010–2012 | 1.47 (0.93 − 2.32) | 0.10 | 1.33 (0.82 − 2.15) | 0.25 |
| 2013–2015 | 1 [Reference] | 1 [Reference] | ||
| Sex | ||||
| Male | 1 [Reference] | – | ||
| Female | 0.84 (0.57 − 1.25) | 0.40 | – | |
| Age | ||||
| < 60 | 1 [Reference] | |||
| 60–75 | 3.20 (1.81 − 5.66) | < 0.001 | 3.38 (1.84 − 6.23) | < 0.001 |
| ≥ 75 | 6.86 (3.68 − 12.82) | < 0.001 | 7.63 (3.86 − 15.07) | < 0.001 |
| Multifocal tumors | ||||
| No | 1 [Reference] | 1 [Reference] | ||
| Yes | 1.40 (0.90 − 2.19) | 0.14 | 1.25 (0.78 − 2.00) | 0.35 |
| Disease stage | ||||
| Stage I-II | 1.60 (0.73 − 2.50) | 0.24 | – | |
| Stage III | 1 [Reference] | 1 [Reference] | ||
| Stage IV | 1.96 (1.25 − 3.06) | 0.003 | 1.86 (1.18 − 2.94) | 0.043 |
| Tumor grade | ||||
| Grade 1 | 1 [Reference] | – | ||
| Grade 2 | 1.33 (0.83 − 2.14) | 0.24 | – | |
| Resection margin | ||||
| R0 | 1 [Reference] | – | ||
| R1/2 | 1.16 (0.67 − 1.99) | 0.60 | – | |
| Surgery | ||||
| Open | 1 [Reference] | 1 [Reference] | ||
| Laparoscopic | 0.47 (0.28 − 0.80) | 0.005 | 0.51 (0.28 − 0.94) | 0.032 |