Table 2.

Serum concentrations and dose-related values of cannabis non-users (control) and users

	Control (n = 17)	Cannabis (n = 15)	p (Student’s t test)	p (Mann–Whitney U test)
Dose	8.8 ± 3.9 mg	8.6 ± 0.9 mg	0.831	0.748
Serum buprenorphine	2.00 ± 3.17 ng/mL	5.41 ± 2.27 ng/mL	0.00167*	0.000249*
Serum norbuprenorphine	1.07 ± 0.82 ng/mL	1.76 ± 1.23 ng/mL	0.0694	0.08576
Active moiety	3.07 ± 3.53 ng/mL	7.17 ± 2.73 ng/mL	0.00103*	0.000632*
Metabolite-to-parent drug ratio	0.98 ± 0.78	0.39 ± 0.44	0.016	0.009171*
Concentration/dose ratio Buprenorphine	0.29 ± 0.36 ng/mL/mg	0.63 ± 0.26 ng/mL/mg	0.00519*	0.00223*
Concentration/dose ratio Norbuprenorphine	0.117 ± 0.077 ng/mL/mg	0.206 ± 0.147 ng/mL/mg	0.0372	0.0518
Active moiety/dose ratio	0.33 ± 0.34 ng/mL/mg	0.83 ± 0.32 ng/mL/mg	0.000141**	0.000268*