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. 2021 Jun 14;26(2):197–215. doi: 10.1007/s10911-021-09491-6

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Fig. 1 — A schematic representation of the hormonal factors and mechanisms that regulate α-lactalbumin (LALBA) transcription. The positive regulators of LALBA transcription are prolactin (PRL) and insulin (INS). Progesterone (P) is a negative regulator of LALBA transcription. Thyroid hormone (T3), estrogen (E), glucocorticoids (GC), and epidermal growth factor (EGF) have variable effects on LALBA transcription that are species- or dose-dependent. Signaling occurs via intermediates including mammalian target of rapamycin (mTOR), phosphatidylinositol 3-kinase (PI3K), and phosphorylated signal transducer and activator of transcription 5 (pSTAT5)