Fig. 1.

SPMs, their receptors, signaling and actions in neutrophils. Simplified biosynthesis pathway of the SPM families namely lipoxins, maresins, resolvins, and protectins with examples of identified receptors. Downstream signaling pathways and polyisoprenyl phosphate remodeling in neutrophils upon LXA₄-ALX interactions: LXA₄ acts as a “stop signal” during inflammation to inhibit PLD, PI3K, NFkB among others and block PSDP turnover to PSMP. PSDP inhibits PLD and PI3K to further reduce pro-inflammatory responses. Red lines represent inhibition, and black arrows represent activation of a pathway. PMN, polymorphonuclear neutrophils. Signaling schematic was adapted from Bonnans et al. and Krishnamoorthy et al. [4, 73]. Created with BioRender.com