Skip to main content
. 2021 Jun 27;79(3):449–459. doi: 10.1007/s12013-021-01012-w

Table 2.

Presqualene diphosphate (PSDP): evidence for roles as a signaling molecule

• Rapid and reciprocal remodeling of PSDP to PSMP upon neutrophil activation by soluble pro-inflammatory stimuli [50]
• PLPP6 (a.k.a. PDP1); a lipid phosphate phosphatase that converts PSDP to PSMP [55]
• Inhibition of PLD and subsequent PA production [51, 52]
• Inhibition of PI3K [53]
• Inhibition of NADPH oxidase assembly and superoxide anion production in neutrophils [50, 51]
• SPMs (i.e., LXA4) inhibit PLPP6 and PSDP conversion to PSMP [55]
• Protective action of PSDP can be replicated by synthetic polyisoprenyl phosphate mimetics [53]