Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 27;11(6):e462. doi: 10.1002/ctm2.462

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Cellular heterogeneity within the gallbladder epithelial and neuroendocrine tumor cells. (A) The t‐SNE plot of the EPCAM+ cells identified three major cell clusters including squamous, glandular, and neuroendocrine epithelial cells. Resolution used for t‐SNE cell grouping analysis 1.2. (B) Violin plots showing the expression levels of biomarkers in the three major cell clusters identified in A. (C) Heatmap of the top 20 differentially expressed genes (based on Wilcoxon test) for each EPCAM+ cell subgroup. (D) The competitive GSEA analysis of the hallmark gene sets (left) and metabolic activity gene sets (right) between the cell subgroups. (E) Monocle 2 trajectory analysis of the epithelial cells derived from GC and adjacent normal tissues annotated by the cellular state (upper) and patient ID (lower). (F) The top 10 differentially expressed genes (based on Wilcoxon test) between the cell state in (E). (G) The competitive GSEA analysis of the hallmark gene sets between the cell subgroups in (E)