TABLE 1.
Diagnostic index of exosomal miRNAs in DM
| Exosomal miRNAs | Types | Sample numbers (nondiabetic/diabetic) | AUC | Sensitivity (%) | Specificity (%) | OR (95% CI) | Ref. |
|---|---|---|---|---|---|---|---|
| miR‐133b | T2DN | 56/110 | 0.867 | 86.4 | 72.7 | 0.820–0.914 | 88 |
| miR‐342 | T2DN | 56/110 | 0.910 | 81.8 | 80.9 | 0.873–0.948 | 88 |
| miR‐30a | T2DN | 56/110 | 0.897 | 76.4 | 90.9 | 0.858–0.936 | 88 |
| miR‐15b | T2DM | 44/136 | 0.883 | 97.8 | 82.2 | 0.824–0.942 | 156 |
| miR‐34a | T2DM | 44/136 | 0.917 | 93.3 | 86.7 | 0.874–0.96 | 156 |
| miR‐636 | T2DM | 44/136 | 0.984 | 97.8 | 93.3 | 0.971–0.997 | 156 |
| miR‐7 | T2DM | 74/76 | 0.75 | — | — | 0.670–0.830 | 157 |
| miR‐7 | T2DMC | 74/76 | 0.77 | — | — | 0.690–0.85 | 157 |
| miR‐133a | T2DM | 12/78 | 0.825 | 78.9 | 74.2 | 0.710–0.940 | 158 |
| miR‐1 | T2DM | 12/78 | 0.886 | 78.9 | 71.0 | 0.765–0.967 | 158 |
| miR‐21‐5p | T2DN | 15/22 | 0.830 | – | – | 0.673–0.986 | 159 |
| miR‐30b‐5p | T2DN | 15/22 | 0.714 | – | – | 0.517–0.911 | 159 |
| let‐7c‐5p | T2DN | 15/28 | 0.818 | 96 | 53.4 | 0.718–0.919 | 160 |
| miR‐424 | T1DM | 30/30 | 0.803 | – | – | – | 161 |
| miR‐218 | T1DM | 30/30 | 0.817 | – | – | – | 161 |
| miR‐491‐5p | Prediabetes | 42/24 | 0.940 | – | – | – | 162 |
| miR‐1307‐3p | Prediabetes | 42/24 | 0.880 | – | – | – | 162 |
| miR‐298 | Prediabetes | 42/24 | 0.840 | – | – | – | 162 |
| miR‐29a | GDM | 55/68 | 0.829 | 76.47 | 78.18 | 0.755–0.903 | 163 |
| miR‐29b | GDM | 55/68 | 0.857 | 85.29 | 81.82 | 0.787–0.926 | 163 |
Note: GDM, gestational diabetes mellitus; T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; T2DMC, T2DM‐associated microvascular complications; T2DN, type 2 diabetic nephropathy.