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. 2021 Jun 26;22:482. doi: 10.1186/s12864-021-07760-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Analysis of the overlap of TFBSs with respect to active cis-regulatory regions in human and mouse. A-B Fraction of TFBSs in the UniBind robust collection (y-axis) with respect to increasing relative distances (x-axis) from ENCODE candidate cis-regulatory regions (cCREs) computed using the bedtools reldist command for human (A) and mouse (B). When two genomic tracks are not spatially related, one expects the fraction of relative distance distribution to be uniform. C Genomic tracks from the UCSC Genome Browser at the human LDLR gene locus (from start to first coding exon) providing information about PhyloP and PhastCons evolutionary conservation scores and the locations of ENCODE cCREs, UniBind CRMs, UniBind TFBSs from the robust collection (using the dense display mode to maximally condense the track) and the non-redundant collection of archetype TFBSs. Colors in the ENCODE cCREs track indicate: promoter-like signature (red), proximal enhancer-like signature (orange), and distal enhancer-like signature (yellow)