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. 2021 Jun 26;22:482. doi: 10.1186/s12864-021-07760-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Correlation between enhancer activity and TF binding. For each enhancer predicted using Cap Analysis of Gene Expression (CAGE) by the FANTOM5 consortium, we computed the number of TFs with overlapping TFBSs in the robust collection of UniBind (x-axis). The figure provides, for each value of the number of TFs found to bind in enhancers, the median (blue line) together with the 10th to 90th percentiles (grey area) of cell type specific activity of these enhancers. The expression measures were derived from CAGE (capturing enhancer RNA expression). The specificity of activity (y-axis) is provided within the [0; 1] range with 0 representing ubiquitous enhancer activity and 1 exclusive expression activity