Fig. 1.

Manhattan plots summarizing epigenome-wide CpG methylation associated with gestational diabetes mellitus. (a–g) Cell type-specific differentially methylated CpG loci are indicated for seven cell types. Results obtained from standard EWAS adjusting for estimated cell type proportions are summarized in (h). CpG loci are aligned on the x-axis according to genomic coordinate and are colored by chromosome. The y-axis represents − log₁₀ (p value). Red dashed lines denote Bonferroni-corrected genome-wide significance threshold (p value < 6.3 $\times$ 10^–8)