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Fasting increases Sirt1 expression and activity. (a) Liver and (b) retinal Sirt1 mRNA expression is increased by IF in mice (48 h fast) when compared with non-fasting controls. (c) IF increases SIRT1 HDAC activity in mouse retinal tissue when compared with non-fasting controls, ***p<0.001. Data are represented as mean ± SEM. Ctl, control; CycloA, cyclophilin A; F355/F460, fluorescence at 355/460 nm
