Table 2. Per-Lesion Diagnostic Performance for 2018 KLCA-NCC PG and LI-RADS v2018 in the Diagnosis of HCC Using Consensus Data.
| 2018 KLCA-NCC PG Definite HCC | LI-RADS v2018 LR-5 | P | 2018 KLCA-NCC PG Definite/Probable HCC | LI-RADS v2018 LR-5/4 | P | ||
|---|---|---|---|---|---|---|---|
| Overall (n = 422) | |||||||
| SEN | 87.2 (204/234) [82.2–91.2] | 80.8 (189/234) [75.1–85.6] | < 0.001 | 89.7 (210/234) [83.2–91.9] | 91.5 (214/234) [87.1–94.7] | 0.204 | |
| SPE | 86.2 (162/188) [80.4–90.8] | 91.0 (171/188) [85.9–94.6] | 0.002 | 83.5 (157/188) [77.4–88.5] | 79.3 (149/188) [79.8–84.8] | 0.071 | |
| PPV | 88.7 (204/230) [84.6–91.8] | 91.8 (189/206) [87.6–94.6] | 87.1 (210/241) [83.0–90.4] | 84.6 (214/253) [80.5–87.9] | |||
| NPV | 84.4 (162/192) [79.4–88.3] | 79.2 (171/216) [74.4–83.2] | 86.7 (157/181) [81.7–90.6] | 88.2 (149/169) [83.0–91.9] | |||
| < 2 cm (n = 173) | |||||||
| SEN | 88.9 (40/45) [76.0–96.3] | 75.6 (34/45) [60.5–87.1] | 0.009 | 91.1 (41/45) [78.8–97.5] | 97.8 (44/45) [88.2–99.9] | 0.073 | |
| SPE | 89.1(114/128) [82.3–93.9] | 94.5 (121/128) [89.1–97.8] | 0.007 | 85.9 (110/128) [78.7–91.5] | 81.3 (104/128) [73.4–87.6] | 0.105 | |
| PPV | 74.1 (40/54) [63.3–82.6] | 82.9 (34/41) [69.9–91.1] | 69.5 (41/59) [59.5–77.9] | 64.7 (44/68) [56.0–72.5] | |||
| NPV | 95.8 (114/119) [90.9–98.1] | 91.7 (121/132) [86.8–94.9] | 96.5 (110/114) [91.5–98.6] | 99.1 (104/105) [93.7–99.9] | |||
| ≥ 2 cm (n = 249) | |||||||
| SEN | 86.8 (164/189) [81.1–91.3] | 82.0 (155/189) [75.8–87.2] | 0.002 | 89.4 (169/189) [84.1–93.4] | 90.0 (170/189) [84.8–93.8] | 0.705 | |
| SPE | 80.0 (48/60) [67.7–89.2] | 83.3 (50/60) [71.5–91.7] | 0.150 | 78.3 (47/60) [65.8–87.9] | 75.0 (45/60) [62.1–85.3] | 0.412 | |
| PPV | 93.2 (164/176) [89.2–95.8] | 93.9 (155/165) [89.8–96.5] | 92.9 (169/182) [88.9–95.5] | 91.9 (170/185) [87.9–94.6] | |||
| NPV | 65.8 (48/73) [56.6–73.9] | 59.5 (50/84) [51.5–67.1] | 70.2 (47/67) [60.3–78.4] | 70.3 (45/64) [60.1–78.8] | |||
Data in parentheses were used to calculate percentages. Data in square brackets are 95% confidence intervals. P values were calculated using generalized estimating equations. HCC = hepatocellular carcinoma, LI-RADS v2018 = Liver Imaging Reporting and Data System version 2018, LR-5 = definitely HCC, LR-5/4 = definitely HCC or probably HCC, NPV = negative predictive value, PPV = positive predictive value, SEN = sensitivity, SPE = specificity, 2018 KLCA-NCC PG = 2018 Korean Liver Cancer Association-National Cancer Center Practice Guidelines