Table 3.
Impact of pre-surgical low-calorie diet on IgG glycosylation.
| Derived IgG glycan trait | Time_effect | Time_SE | Time_p value | Adjusted p value |
|---|---|---|---|---|
| Bisecting GlcNAc (B) | −0.2801 | 0.0743 | 4.30 × 10−03 | 3.41 × 10−02 |
| Agalactosylation (G0) | −0.0493 | 0.1876 | 7.93 × 10−01 | 7.93 × 10−01 |
| Monogalactosylation (G1) | 0.1122 | 0.1869 | 5.53 × 10−01 | 7.93 × 10−01 |
| Digalactosylation (G2) | −0.0539 | 0.1387 | 6.99 × 10−01 | 7.93 × 10−01 |
| Total sialylation (S) | 0.0941 | 0.2090 | 6.54 × 10−01 | 7.93 × 10−01 |
| Monosialylation (S1) | 0.1354 | 0.1878 | 4.78 × 10−01 | 7.93 × 10−01 |
| Disialylation (S2) | −0.0869 | 0.2474 | 7.27 × 10−01 | 7.93 × 10−01 |
| Core fucosylation (CF) | 0.0810 | 0.2416 | 7.39 × 10−01 | 7.93 × 10−01 |
Longitudinal analysis was performed by implementing a linear mixed effects model, with time as a fixed effect and the individual sample measurement as a random effect. False discovery rate was controlled using Benjamini–Hochberg method at the specified level of 0.05.
Bold – significant decrease; Underline – non-significant change.
GlcNAc N-acetylglucosamine, SE standard error.