Table 4.
Bariatric surgery induces significant changes in IgG N-glycome.
| Derived IgG glycan trait | Time_effect | Time_SE | Time_p value | Adjusted p value |
|---|---|---|---|---|
| Agalactosylation (G0) | −0.0339 | 0.0078 | 9.23 × 10−05 | 7.38 × 10−04 |
| Digalactosylation (G2) | 0.0275 | 0.0072 | 3.75 × 10−04 | 1.50 × 10−03 |
| Monosialylation (S1) | 0.0193 | 0.0080 | 1.97 × 10−02 | 3.94 × 10−02 |
| Core fucosylation (CF) | −0.0155 | 0.0064 | 1.74 × 10−02 | 3.94 × 10−02 |
| Total sialylation (S) | 0.0171 | 0.0083 | 4.70 × 10−02 | 6.27 × 10−02 |
| Bisecting GlcNAc (B) | 0.0173 | 0.0083 | 4.01 × 10−02 | 6.27 × 10−02 |
| Monogalactosylation (G1) | 0.0206 | 0.0107 | 8.18 × 10−02 | 9.35 × 10−02 |
| Disialylation (S2) | 0.0048 | 0.0080 | 5.48 × 10−01 | 5.48 × 10−01 |
Longitudinal analysis was performed by implementing a linear mixed effects model, with time as a fixed effect and the individual sample measurement as a random effect. False discovery rate was controlled using Benjamini–Hochberg method at the specified level of 0.05.
Bold – significant decrease; Underline – significant increase; Italic – non-significant change.
GlcNAc N-acetylglucosamine, SE standard error.