Table 5.
Longitudinally monitored weight loss-associated significant changes of IgG N-glycosylation.
| Derived IgG glycan trait | BMI difference effect (glycan abundance (%) change per 1 kg/m2 decrease in BMI) | BMI difference SE (glycan abundance (%) change per 1 kg/m2 decrease in BMI) | p value | Adjusted p value |
|---|---|---|---|---|
| Digalactosylation (G2) | 0.2004 | 0.0403 | 6.88 × 10−07 | 5.85 × 10−06 |
| High mannose (HM) | −0.0519 | 0.0119 | 1.33 × 10−05 | 5.66 × 10−05 |
| Agalactosylation (G0) | −0.1048 | 0.0397 | 8.43 × 10−03 | 1.79 × 10−02 |
| Bisecting GlcNAc (B) | 0.0526 | 0.0262 | 4.49 × 10−02 | 6.94 × 10−02 |
| Monogalactosylation (G1) | −0.0573 | 0.0343 | 9.53 × 10−02 | 1.25 × 10−01 |
| Core fucosylation (CF) | −0.0059 | 0.0285 | 8.36 × 10−01 | 8.89 × 10−01 |
Longitudinal analysis was performed by implementing a mixed model, fitted to estimate the effect of BMI change on IgG N-glycome. False discovery rate was controlled using Benjamini–Hochberg method at the specified level of 0.05.
Bold – significant decrease; Underline – significant increase; Italic – non-significant change.
BMI body mass index, GlcNAc N-acetylglucosamine, SE standard error.