Table 1.
Overview of patient characteristics (n = 270) in relation to HPV-status of the tumor
| HPV-status | p value | |||||
|---|---|---|---|---|---|---|
| Negative N = 192 | % (71.1) | Positive N = 78 | % (28.9) | |||
| Age, years Mean age (SD) | 59.9 (8.7) | 59.9 (8.2) | 0.95 | |||
| Sex | Male | 120 | 62.5% | 59 | 75.6% | 0.038 |
| Female | 72 | 37.5% | 19 | 24.4% | ||
| Comorbidity | None | 65 | 33.9% | 42 | 53.8% | 0.026 |
| Mild | 59 | 30.7% | 17 | 21.8% | ||
| Moderate | 54 | 28.1% | 15 | 19.2% | ||
| Severe | 14 | 7.3% | 4 | 5.1% | ||
| Smoking | No smoking | 17 | 8.9% | 33 | 42.9% | < 0.001 |
| 1–24 pack years | 24 | 12.6% | 18 | 23.4% | ||
| > 24 pack years | 150 | 78.5% | 26 | 33.8% | ||
| Alcohol use | No alcohol use | 19 | 10.0% | 24 | 31.2% | < 0.001 |
| 1–149 units per year | 41 | 21.6% | 29 | 37.7% | ||
| > 149 units per year | 130 | 68.4% | 24 | 31.2% | ||
| Tumor location | Base of tongue | 44 | 22.9% | 23 | 29.5% | < 0.001 |
| Soft palate | 37 | 19.3% | 4 | 5.1% | ||
| Tonsil | 74 | 38.5% | 48 | 61.5% | ||
| Oropharynx nos | 37 | 19.3% | 3 | 3.8% | ||
| TNM classification | Stage I | 27 | 14.1% | 10 | 12.8% | 0.24 |
| Stage II | 47 | 24.5% | 14 | 17.9% | ||
| Stage III | 45 | 23.4% | 14 | 17.9% | ||
| Stage IV A–B | 73 | 38% | 40 | 51.3% | ||
| Treatment | Single treatment* | 103 | 53.6% | 25 | 32.1% | 0.001 |
| Combination treatment | 89 | 46.4% | 53 | 67.9% | ||
HPV human papilloma virus; SD standard deviation; nos not otherwise specified
*This comprised RT: n = 99, surg n = 4